Global flu pandemic led to extensive research after 30 to 50 million people died of flu1
Scientists discover that flu virus
can be grown in eggs2
First egg-based vaccine is developed3
First human flu vaccines tested4
Scientists discover that flu strains
Cell cultures are used for many vaccines such as measles, mumps, and rubella6
Clinical development of cell culture-based flu vaccines begins7
FDA approves first cell culture-based flu virus vaccine, FLUCELVAX® (Influenza Vaccine)8,9
FDA licenses Holly Springs, North Carolina, vaccine production plant to make cell culture-based flu vaccines. Flucelvax is produced in the United States for the first time10
FDA approves FLUCELVAX QUADRIVALENT, the first and only cell culture-based flu vaccine in the United States to help offer protection against 4 flu virus strains for people aged 4 years and older9,11
References: 1. US Department of Health and Human Services. The pandemic. http://www.flu.gov/pandemic/history/1918/the_pandemic/index.html. Accessed July 20, 2015.
2. Artenstein AW, Opal JM, Opal SM, Tramont EC, Peter G, Russell PK. History of U.S. military contributions to the study of vaccines against infectious diseases. Mil Med.
2005;170(suppl 4):3-11. 3. DuBois LA. Ernest Goodpasture and the mass production of vaccines. Vanderbilt Medical Center website. http://www.mc.vanderbilt.edu/lens/article/?id=92&pg=999. Published April 2004. Accessed July 20, 2015. 4. Francis T Jr. Vaccination against influenza. Bull World Health Organ. 1953;8(5-6):725-741. 5. Andrewes CH. Influenza: theme and variations. Calif Med. 1956;84(6):375-380. 6. Human cell strains in vaccine development. The College of Physicians of Philadelphia website. http://www.historyofvaccines.org/content/articles/human-cell-strains-vaccine-development. Accessed July 20, 2015. 7. US Food and Drug Administration. Summary minutes: Vaccines and Related Biological Products Advisory Committee: Meeting #104: November 16-17, 2005. http://www.fda.gov/ohrms/dockets/ac/05/minutes/2005-4188m1.pdf. Accessed July 20, 2015. 8. FLUCELVAX (Influenza Vaccine) [package insert]. Holly Springs, NC: Seqirus Inc; 2015. 9. US Food and Drug Administration. FDA approves first seasonal influenza vaccine manufactured using cell culture technology. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm328982.htm. Updated 2012. Accessed September 9, 2015. 10. A milestone in protection from influenza. US Department of Health and Human Services website. http://www.hhs.gov/news/press/2014pres/06/20140617a.html. Accessed July 20, 2015. 11. FLUCELVAX QUADRIVALENT [package insert]. Holly Springs, NC: Seqirus Inc; 2016.
FLUCELVAX QUADRIVALENT is a vaccine that helps protect against influenza (flu). FLUCELVAX is for people aged 4 and older. Vaccination with FLUCELVAX QUADRIVALENT may not protect all people who receive the vaccine.
You should not get FLUCELVAX QUADRIVALENT if you have had a severe allergic reaction to any of the ingredients in the vaccine.